Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13728

Ethylene oxide: Target Organs and Levels of Evidence for TR-326

Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Ethylene oxide
75-21-8
08/19/1986Accelerates ripening in fruit and maturing of tobacco leaves. Fungistat. Rocket propellant. Fumigant for foodstuffs and textiles. Organic synthesis. Sterilize surgical instruments. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,50,100 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50
  • Harderian Gland: CYSTADENOMA 1/43 9/44 8/42
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49
  • Harderian Gland: CYSTADENOMA 1/46 6/46 8/47
  • Uterus/Cervix: ADENOCARCINOMA 0/49 1/47 5/49
  • Mammary Gland: ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49
  • Hematopoietic System: LYMPHOMA 9/49 6/48 22/49