Target Organs and Levels of Evidence for TR-328
Toxicology and Carcinogenesis Studies of Methyl Carbamate (CASRN 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Methyl carbamate 598-55-0 |
08/19/1986 |
Gavage R: 0,100,200, M: 0,500,1000 MG/KG/50 PER GROUP |
BioReliance, Inc |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49
|
Non-Neoplastic Lesions |
- HARDERIAN GLAND: INFLAMMATION 4/50 11/50 16/50
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50
|
Non-Neoplastic Lesions |
- HARDERIAN GLAND: INFLAMMATION 7/50 16/50 30/50
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: HYPERPLASIA, ADENOMATOUS 13/50 19/50 24/49; HISTIOCYTOSIS 11/50 7/50 21/49
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: HYPERPLASIA, ADENOMATOUS 7/49 10/50 18/50; HISTIOCYTOSIS 9/49 10/50 21/50
|