Methyl carbamate: Target Organs and Levels of Evidence for TR-328
Toxicology and Carcinogenesis Studies of Methyl Carbamate (CASRN 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Methyl carbamate
598-55-0 | 08/19/1986 | Gavage
R: 0,100,200, M: 0,500,1000 MG/KG/50 PER GROUP | BioReliance, Inc |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49
|
| Non-Neoplastic Lesions | - HARDERIAN GLAND: INFLAMMATION 4/50 11/50 16/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50
|
| Non-Neoplastic Lesions | - HARDERIAN GLAND: INFLAMMATION 7/50 16/50 30/50
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: HYPERPLASIA, ADENOMATOUS 13/50 19/50 24/49; HISTIOCYTOSIS 11/50 7/50 21/49
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: HYPERPLASIA, ADENOMATOUS 7/49 10/50 18/50; HISTIOCYTOSIS 9/49 10/50 21/50
|
