Skip to Main Navigation Skip to Page Content

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Target Organs and Levels of Evidence for TR-329

Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
1,2-Epoxybutane 106-88-7	08/19/1986	Inhalation R: 0,200,400, M: 0,50,100 PPM/50 PER GROUP	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Nasal Cavity: ADENOMA 0/50 0/50 7/50 Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49
Non-Neoplastic Lesions	NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS, INFLAMMATION, SUPPURATIVE

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Nasal Cavity: ADENOMA 0/50 0/50 2/50
Non-Neoplastic Lesions	NASAL CAVITY: HYPERPLASIA, ADENOMATOUS; INFLAMMATION, NOS; INFLAMMATION, SEROUS; INFLAMMATION, SUPPURATIVE

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	NASAL CAVITY: INFLAMMATION, CHRONIC

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	NASAL CAVITY: INFLAMMATION, CHRONIC