Malonaldehyde, sodium salt: Target Organs and Levels of Evidence for TR-331
Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Malonaldehyde, sodium salt
24382-04-5 | 03/04/1987 | Gavage
R: 0,50,100, M: 0,60,120 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50
|
| May Have Been Related | - Pancreas Islet Cell:
ADENOMA 0/49 9/50 1/49
|
| Non-Neoplastic Lesions | - GLANDULAR STOMACH: ULCERS; INFLAMMATION
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACT, CRYSTALLINE LENS
- LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50
|
| Non-Neoplastic Lesions | - GLANDULAR STOMACH: ULCERS; INFLAMMATION
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACTS, CRYSTALLINE LENS
- LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - PANCREATIC ACINUS: ATROPHY
- HAIR SHAFTS: PIGMENTATION LOSS
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - PANCREATIC ACINUS: ATROPHY
- HAIR SHAFTS: PIGMENTATION LOSS
|
