Target Organs and Levels of Evidence for TR-331
Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Malonaldehyde, sodium salt
24382-04-5 |
03/04/1987 |
Gavage
R: 0,50,100, M: 0,60,120 MG/KG/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50
|
| May Have Been Related |
- Pancreas Islet Cell: ADENOMA 0/49 9/50 1/49
|
| Non-Neoplastic Lesions |
- GLANDULAR STOMACH: ULCERS; INFLAMMATION
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACT, CRYSTALLINE LENS
- LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50
|
| Non-Neoplastic Lesions |
- GLANDULAR STOMACH: ULCERS; INFLAMMATION
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACTS, CRYSTALLINE LENS
- LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- PANCREATIC ACINUS: ATROPHY
- HAIR SHAFTS: PIGMENTATION LOSS
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- PANCREATIC ACINUS: ATROPHY
- HAIR SHAFTS: PIGMENTATION LOSS
|
