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Target Organs and Levels of Evidence for TR-331

Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Malonaldehyde, sodium salt 24382-04-5	03/04/1987	Gavage R: 0,50,100, M: 0,60,120 MG/KG/50 PER GROUP	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50
May Have Been Related	Pancreas Islet Cell: ADENOMA 0/49 9/50 1/49
Non-Neoplastic Lesions	GLANDULAR STOMACH: ULCERS; INFLAMMATION FORESTOMACH: HYPERPLASIA, EPITHELIAL EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACT, CRYSTALLINE LENS LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT

Female Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50
Non-Neoplastic Lesions	GLANDULAR STOMACH: ULCERS; INFLAMMATION FORESTOMACH: HYPERPLASIA, EPITHELIAL EYE: INFLAMMATION, CORNEA; ATROPHY, RETINA; CATARACTS, CRYSTALLINE LENS LIVER: DEGENERATION, CYSTIC; FIBROSIS, BILE DUCT; HYPERPLASIA, BILE DUCT

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	PANCREATIC ACINUS: ATROPHY HAIR SHAFTS: PIGMENTATION LOSS

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	PANCREATIC ACINUS: ATROPHY HAIR SHAFTS: PIGMENTATION LOSS