2-Mercaptobenzothiazole: Target Organs and Levels of Evidence for TR-332
Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
2-Mercaptobenzothiazole
149-30-4 | 03/04/1987 | Gavage
FR: 0,188,375, MR&M: 0,375,750 MG/KG/50 PER GROUP | Physiological Research Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LEUKEMIA 7/50 16/50 3/50
- Pancreas Acinar Cell:
ADENOMA 2/50 13/50 6/50
- Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49
- Preputial Gland:
ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 1/50 5/50 6/50
- Pituitary Gland:
ADENOMA 15/49 24/50 25/50
|
Male Mice: No Evidence
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 3/50 7/49 4/50 OR CARCINOMA 1/50 5/49 0/50 COMBINED 4/50 12/49 4/50
|
