N-Phenyl-2-naphthylamine: Target Organs and Levels of Evidence for TR-333
Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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N-Phenyl-2-naphthylamine 135-88-6 | 03/04/1987 | Dosed-Feed 0,2500,5000 PPM/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type | Organ/Tissue (Lesion) |
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Non-Neoplastic Lesions | - KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
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Non-Neoplastic Lesions | - KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE; MINERALIZATION; NECROSIS; CALCULI; HYPERPLASIA; HYDRONEPHROSIS; ATROPHY; FIBROSIS
|
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 0/50 1/47 OR ADENOCARCINOMA 0/50 0/50 1/50
|
Non-Neoplastic Lesions | - KIDNEY: KARYOMEGALY; NEPHROPATHY
|