Target Organs and Levels of Evidence for TR-333
Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
N-Phenyl-2-naphthylamine 135-88-6 |
03/04/1987 |
Dosed-Feed 0,2500,5000 PPM/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE; MINERALIZATION; NECROSIS; CALCULI; HYPERPLASIA; HYDRONEPHROSIS; ATROPHY; FIBROSIS
|
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 0/50 1/47 OR ADENOCARCINOMA 0/50 0/50 1/50
|
Non-Neoplastic Lesions |
- KIDNEY: KARYOMEGALY; NEPHROPATHY
|