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https://ntp.niehs.nih.gov/go/13742

Target Organs and Levels of Evidence for TR-333

Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
N-Phenyl-2-naphthylamine
135-88-6		 03/04/1987 Dosed-Feed
0,2500,5000 PPM/50 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS; INFLAMMATION, CHRONIC; INFLAMMATION, ACUTE SUPPURATIVE; MINERALIZATION; NECROSIS; CALCULI; HYPERPLASIA; HYDRONEPHROSIS; ATROPHY; FIBROSIS
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/47 OR ADENOCARCINOMA 0/50 0/50 1/50
Non-Neoplastic Lesions
  • KIDNEY: KARYOMEGALY; NEPHROPATHY