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Target Organs and Levels of Evidence for TR-334

Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
2-Amino-5-nitrophenol 121-88-0	03/04/1987	Gavage R: 0,100,200, M: 0,400,800 MG/KG/50 PER GROUP	Physiological Research Laboratory

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Pancreas Acinar Cell: ADENOMA 1/50 10/50 3/49
May Have Been Related	Preputial Gland: ADENOMA 3/50 2/50 1/50 OR CARCINOMA 0/50 0/50 4/50 COMBINED 3/50 2/50 5/50

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Clitoral Gland: ADENOMA 2/50 1/50 7/50 OR CARCINOMA 1/50 2/50 0/50 COMBINED 3/50 3/50 7/50

Target Organs and Levels of Evidence for TR-334

Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Levels of Evidence

Male Rats: Some Evidence

Female Rats: No Evidence

Male Mice: No Evidence

Female Mice: No Evidence