C.I. Acid Orange 3: Target Organs and Levels of Evidence for TR-335
Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
C.I. Acid orange 3
6373-74-6 | 07/14/1987 | Gavage
R: 0,375,750 MG/KG MM: 0,125,250 MG/KG FM: 0,250,500 MG/KG/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 37/50 44/50; PIGMENTATION 4/50 4/50 39/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 6/50 13/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Transitional Cell:
CARCINOMA 0/50 0/50 6/50
|
| Non-Neoplastic Lesions | - KIDNEY: INFLAMMATION, SUPPURATIVE 0/50 10/50 45/50; PIGMENTATION 0/50 0/50 5/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 2/50 13/50; NEPHROPATHY 23/50 45/50 48/50; NECROSIS, PAPILLA 0/50 0/50 10/50
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: INFLAMMATION, SUPPURATIVE 1/50 4/50 12/50; FIBROSIS 0/50 5/50 19/50; NECROSIS 0/50 0/50 7/50; DEGENERATION, PAPILLA 0/50 4/50 18/50; DILATATION, TUBULE 2/50 39/50 33/50
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 7/50 22/50; FIBROSIS 4/50 9/50 31/50; NECROSIS 2/50 5/50 8/50; DEGENERATION, PAPILLA 0/50 3/50 19/50; DILATATION, TUBULE 2/50 35/50 42/50; NEPHROSIS 13/50 42/50 50/50; MINERALIZATION, TUBULE 3/50 15/50 22/50
|
