Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13746

Target Organs and Levels of Evidence for TR-335

Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
C.I. Acid orange 3
6373-74-6
07/14/1987 Gavage
R: 0,375,750 MG/KG MM: 0,125,250 MG/KG FM: 0,250,500 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 37/50 44/50; PIGMENTATION 4/50 4/50 39/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 6/50 13/50
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA 0/50 0/50 6/50
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 0/50 10/50 45/50; PIGMENTATION 0/50 0/50 5/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 2/50 13/50; NEPHROPATHY 23/50 45/50 48/50; NECROSIS, PAPILLA 0/50 0/50 10/50
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 1/50 4/50 12/50; FIBROSIS 0/50 5/50 19/50; NECROSIS 0/50 0/50 7/50; DEGENERATION, PAPILLA 0/50 4/50 18/50; DILATATION, TUBULE 2/50 39/50 33/50
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 7/50 22/50; FIBROSIS 4/50 9/50 31/50; NECROSIS 2/50 5/50 8/50; DEGENERATION, PAPILLA 0/50 3/50 19/50; DILATATION, TUBULE 2/50 35/50 42/50; NEPHROSIS 13/50 42/50 50/50; MINERALIZATION, TUBULE 3/50 15/50 22/50