Target Organs and Levels of Evidence for TR-337
Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Nitrofurazone 59-87-0 |
07/14/1987 |
Dosed-Feed R: 0,310,620, M: 0,150,310 PPM/50 PER GROUP |
Physiological Research Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Preputial Gland: ADENOMA 8/50 8/50 2/50 OR CARCINOMA 1/50 8/50 5/50 COMBINED 9/50 16/50 7/50
- Skin: SEBACEOUS GLAND ADENOMA 0/50 0/50 4/50; TRICHOEPITHELIOMA 0/50 0/50 1/50
- Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA 0/50 7/50 2/50
|
Non-Neoplastic Lesions |
- TESTES: DEGENERATION 12/50 49/50 47/50
- KNEE JOINT: DEGENERATION 5/50 32/50 48/50
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Mammary Gland: FIBROADENOMA 8/49 36/50 36/50
|
Non-Neoplastic Lesions |
- KNEE JOINT: DEGENERATION 4/49 30/50 39/50
|
Male Mice: No Evidence
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Ovary: GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50
|
Non-Neoplastic Lesions |
- OVARY: ATROPHY 7/47 44/50 38/50
|