Nitrofurazone: Target Organs and Levels of Evidence for TR-337
Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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Nitrofurazone 59-87-0 | 07/14/1987 | Dosed-Feed R: 0,310,620, M: 0,150,310 PPM/50 PER GROUP | Physiological Research Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Preputial Gland:
ADENOMA 8/50 8/50 2/50 OR CARCINOMA 1/50 8/50 5/50 COMBINED 9/50 16/50 7/50
- Skin:
SEBACEOUS GLAND ADENOMA 0/50 0/50 4/50; TRICHOEPITHELIOMA 0/50 0/50 1/50
- Mesothelium (Abdominal Cavity/Tunica Vaginalis):
MESOTHELIOMA 0/50 7/50 2/50
|
Non-Neoplastic Lesions | - TESTES: DEGENERATION 12/50 49/50 47/50
- KNEE JOINT: DEGENERATION 5/50 32/50 48/50
|
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Mammary Gland:
FIBROADENOMA 8/49 36/50 36/50
|
Non-Neoplastic Lesions | - KNEE JOINT: DEGENERATION 4/49 30/50 39/50
|
Male Mice: No Evidence
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Ovary:
GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50
|
Non-Neoplastic Lesions | - OVARY: ATROPHY 7/47 44/50 38/50
|