Target Organs and Levels of Evidence for TR-340
Toxicology and Carcinogenesis Studies of Iodinated Glycerol (Organidin) (CASRN 5634-39-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Iodinated glycerol
5634-39-9 |
10/04/1988 |
Gavage
FR&FM: 0, 62, 125, MR&MM: 0, 125, 250 MG/KG/50 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Hematopoietic System: LEUKEMIA 14/50 29/50 24/50
- Thyroid Gland Follicular Cell: CARCINOMA 0/49 5/49 1/49
|
| May Have Been Related |
- Nasal Cavity: ADENOMA 0/48 0/47 2/49
|
| Non-Neoplastic Lesions |
- SALIVARY GLAND: ATROPHY, FOCAL 1/48 10/50 30/49; METAPLASIA, SQUAMOUS 0/48 47/50 48/49
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SALIVARY GLAND: ATROPHY, FOCAL 0/49 4/50 11/50; METAPLASIA, SQUAMOUS 1/49 48/50 49/50
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL 3/48 46/50 34/50; DILATATION, FOLLICLE 0/48 28/50 32/50
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Pituitary Gland: ADENOMA 10/47 15/45 24/46
- Harderian Gland: ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50
|
| May Have Been Related |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49
|
| Non-Neoplastic Lesions |
- THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL 2/48 25/48 35/48; DILATATION, FOLLICLE 4/48 11/48 10/48
|
