Nitrofurantoin: Target Organs and Levels of Evidence for TR-341
Toxicology and Carcinogenesis Studies of Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Nitrofurantoin 67-20-9 | 04/18/1988 | Dosed-Feed FR: 0,600,1300, MR&M: 0,1300,2500 PPM/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50
|
May Have Been Related | - Bone:
OSTEOSARCOMA 0/50 1/50 2/50
- Subcutaneous Tissue:
FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50
|
Non-Neoplastic Lesions | - KIDNEY: NEPHROPATHY, CHRONIC 50/50 48/50 48/50
- TESTES: DEGENERATION 0/50 0/50 36/50
|
Female Rats: No Evidence
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - TESTES: GERMINAL EPITHELIUM, DEGENERATION 0/49 3/49 23/50
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Ovary:
TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50
|
Non-Neoplastic Lesions | - OVARY: ATROPHY 0/50 48/50 49/50
- ADRENAL GLAND: SPINDLE CELL, HYPERPLASIA 3/50 41/50 45/50
|