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https://ntp.niehs.nih.gov/go/13758

Nitrofurantoin: Target Organs and Levels of Evidence for TR-341

Toxicology and Carcinogenesis Studies of Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Nitrofurantoin
67-20-9		04/18/1988Dosed-Feed
FR: 0,600,1300, MR&M: 0,1300,2500 PPM/50 PER GROUP		Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50
May Have Been Related
  • Bone: OSTEOSARCOMA 0/50 1/50 2/50
  • Subcutaneous Tissue: FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY, CHRONIC 50/50 48/50 48/50
  • TESTES: DEGENERATION 0/50 0/50 36/50
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • TESTES: GERMINAL EPITHELIUM, DEGENERATION 0/49 3/49 23/50
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Ovary: TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50
Non-Neoplastic Lesions
  • OVARY: ATROPHY 0/50 48/50 49/50
  • ADRENAL GLAND: SPINDLE CELL, HYPERPLASIA 3/50 41/50 45/50