Target Organs and Levels of Evidence for TR-342
Toxicology and Carcinogenesis Studies of Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Dichlorvos
62-73-7 |
07/14/1987 |
Gavage
R: 0,4,8, MM: 0,10,20, FM: 0,20,40 MG/KG/50 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Pancreas Acinar Cell: ADENOMA 25/50 30/49 33/50
- Hematopoietic System: LEUKEMIA 11/50 20/50 21/50
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Pancreas Acinar Cell: ADENOMA 2/50 3/47 6/50
- Mammary Gland: FIBROADENOMA 9/50 19/50 16/50 OR ADENOMA 0/50 0/50 1/50 COMBINED 9/50 19/50 17/50
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 1/50 5/50
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 5/49 6/49 18/50
|
