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Target Organs and Levels of Evidence for TR-345

Toxicology and Carcinogenesis Studies of Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Roxarsone 121-19-7	11/06/1987	Dosed-Feed R: 0,50,100 M: 0,100,200 PPM/50 PER GROUP	Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Pancreas Acinar Cell: ADENOMA 1/50 1/50 5/50

Target Organs and Levels of Evidence for TR-345

Toxicology and Carcinogenesis Studies of Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Levels of Evidence

Male Rats: Equivocal Evidence

Female Rats: No Evidence

Male Mice: No Evidence

Female Mice: No Evidence