Target Organs and Levels of Evidence for TR-346
Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Chloroethane
75-00-3 |
10/03/1988 |
Inhalation
R&M: 0, 15000 PPM/50 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Skin: TRICHOEPITHELIOMA 0/49 1/46, SEBACEOUS GLAND ADENOMA 0/49 1/46, OR BASAL CELL CARCINOMA 0/49 3/46 COMBINED 0/49 5/46
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Brain: ASTROCYTOMA 0/50 3/50
|
Male Mice: Inadequate Study
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Uterus/Cervix: ENDOMETRIAL CARCINOMA 0/49 43/50
|
| May Have Been Related |
- Liver: ADENOMA 0/49 1/48 OR CARCINOMA 3/49 7/48 COMBINED 3/49 8/48
|
