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Target Organs and Levels of Evidence for TR-348

Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CASRN 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Methyldopa sesquihydrate 41372-08-1	11/06/1987	Dosed-Feed R: 0, 3100, 6300, M: 0, 6300, 12500 PPM/50 PER GROUP	Physiological Research Laboratory

Levels of Evidence

Male Rats: No Evidence

Female Rats: No Evidence

Male Mice: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA 0/50 2/50 0/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 2/50 1/50

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: CYSTS 2/50 10/50 10/50; NEPHROPATHY 3/50 21/50 32/50; KARYOMEGALY 0/50 46/50 44/50