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Target Organs and Levels of Evidence for TR-351

Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
p-Chloroaniline hydrochloride
20265-96-7		 04/18/1988 Gavage
R: 0,2,6,18, M: 0,3,10,30 MG/KG/50 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50
May Have Been Related
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49
Non-Neoplastic Lesions
  • SPLEEN: FIBROSIS 3/49 11/50 12/50 41/50
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: FIBROSARCOMA 0/50 0/50 1/50 0/50 OR OSTEOSARCOMA 0/50 0/50 0/50 1/50 COMBINED 0/50 0/50 1/50 1/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 3/50 1/50 6/50
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Liver): HEMANGIOSARCOMA 2/50 2/50 1/49 6/50
  • Liver: ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50
  • Vascular System (Spleen): HEMANGIOSARCOMA 3/50 2/47 0/49 5/49
Female Mice: No Evidence