p-Chloroaniline hydrochloride: Target Organs and Levels of Evidence for TR-351
Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
p-Chloroaniline hydrochloride
20265-96-7 | 04/18/1988 | Gavage
R: 0,2,6,18, M: 0,3,10,30 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Spleen:
FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50
|
| May Have Been Related | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49
|
| Non-Neoplastic Lesions | - SPLEEN: FIBROSIS 3/49 11/50 12/50 41/50
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Spleen:
FIBROSARCOMA 0/50 0/50 1/50 0/50 OR OSTEOSARCOMA 0/50 0/50 0/50 1/50 COMBINED 0/50 0/50 1/50 1/50
- Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 2/50 3/50 1/50 6/50
|
Male Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Vascular System (Liver):
HEMANGIOSARCOMA 2/50 2/50 1/49 6/50
- Liver:
ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50
- Vascular System (Spleen):
HEMANGIOSARCOMA 3/50 2/47 0/49 5/49
|
Female Mice: No Evidence
