Furosemide: Target Organs and Levels of Evidence for TR-356
Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Furosemide
54-31-9 | 04/18/1988 | Dosed-Feed
R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP | SRI International |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 1/50 3/50 1/50 OR CARCINOMA 0/50 1/50 1/50 COMBINED 1/50 4/50 2/50
- Brain:
MENINGIOMA 0/50 3/50 0/50
|
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: No Evidence
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Mammary Gland:
ADENOCARCINOMA 0/50 2/50 5/48
|
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
