Target Organs and Levels of Evidence for TR-356
Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Furosemide
54-31-9 |
04/18/1988 |
Dosed-Feed
R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP |
SRI International |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 1/50 3/50 1/50 OR CARCINOMA 0/50 1/50 1/50 COMBINED 1/50 4/50 2/50
- Brain: MENINGIOMA 0/50 3/50 0/50
|
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: No Evidence
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Mammary Gland: ADENOCARCINOMA 0/50 2/50 5/48
|
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
