Target Organs and Levels of Evidence for TR-357
Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Hydrochlorothiazide
58-93-5 |
04/18/1988 |
Dosed-Feed
R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP |
SRI International |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 3/48 8/49 14/50 OR CARCINOMA 4/48 4/49 9/50 COMBINED 7/48 10/49 21/50
|
Female Mice: No Evidence
