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Target Organs and Levels of Evidence for TR-358

Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Ochratoxin A
303-47-9		 04/18/1988 Gavage
R: 0, 21, 70, 210 MG/KG		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 1/50 1/51 16/51 24/50, PROLIFERATION 0/50 0/51 10/51 26/50, CYTOPLASMIC ALTERATION 1/50 0/51 3/51 8/50, KARYOMEGALY 0/50 1/51 51/51 50/50, DEGENERATION 0/50 0/51 50/51 49/50
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50
  • Mammary Gland: FIBROADENOMA 17/50 23/51 22/50 28/50
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 0/50 0/51 12/50 13/50, PROLIFERATION 0/50 0/51 3/50 16/50, KARYOMEGALY 0/50 8/51 50/50 50/50, DEGENERATION 0/50 0/51 49/50 49/50