Target Organs and Levels of Evidence for TR-358
Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Ochratoxin A 303-47-9 |
04/18/1988 |
Gavage R: 0, 21, 70, 210 MG/KG |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50
|
Non-Neoplastic Lesions |
- KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 1/50 1/51 16/51 24/50, PROLIFERATION 0/50 0/51 10/51 26/50, CYTOPLASMIC ALTERATION 1/50 0/51 3/51 8/50, KARYOMEGALY 0/50 1/51 51/51 50/50, DEGENERATION 0/50 0/51 50/51 49/50
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50
- Mammary Gland: FIBROADENOMA 17/50 23/51 22/50 28/50
|
Non-Neoplastic Lesions |
- KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 0/50 0/51 12/50 13/50, PROLIFERATION 0/50 0/51 3/50 16/50, KARYOMEGALY 0/50 8/51 50/50 50/50, DEGENERATION 0/50 0/51 49/50 49/50
|