https://ntp.niehs.nih.gov/go/8917

Target Organs and Levels of Evidence for TR-360

Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
N,N-Dimethylaniline
121-69-7		 03/13/1989 Gavage
R: 0,3,30, M: 0,15,30 MG/KG/50 PER GROUP		 Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50
Non-Neoplastic Lesions
  • SPLEEN: FIBROSIS 5/49 2/49 22/50; HEMOSIDEROSIS 43/49 47/49 49/50; METAMORPHOSIS, FATTY 0/49 1/49 10/50
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 2/50 8/50