https://ntp.niehs.nih.gov/go/8921

Target Organs and Levels of Evidence for TR-362

Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
4-Vinyl-1-cyclohexene diepoxide
106-87-6		 03/13/1989 Topical Application
R: 0, 50, 100, M: 0, 25, 50, 100 MG/ML/60 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50
  • Ovary: BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50
May Have Been Related
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50