4-Vinyl-1-cyclohexene diepoxide: Target Organs and Levels of Evidence for TR-362
Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
4-Vinyl-1-cyclohexene diepoxide
106-87-6 | 03/13/1989 | Topical Application
R: 0, 50, 100, M: 0, 25, 50, 100 MG/ML/60 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Skin:
BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Skin:
BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Skin:
SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Skin:
SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50
- Ovary:
BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50
|
| May Have Been Related | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50
|
