Bromoethane (ethyl bromide): Target Organs and Levels of Evidence for TR-363
Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CASRN 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Bromoethane (ethyl bromide)
74-96-4 | 10/03/1988 | Inhalation
R&M: 0,100,200,400 PPM/50 PER GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 8/48 23/47 17/50 21/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 2/50 0/49 COMBINED 8/48 23/47 18/50 21/49
|
| May Have Been Related | - Brain:
GRANULAR CELL TUMOR 0/49 3/50 1/50 1/50; GLIOMA 0/49 1/50 0/50 0/50, ASTROCYTOMA 0/49 1/50 0/50 0/50, OR OLIGODENDROGLIOMA 0/49 1/50 0/50 0/50 COMBINED 0/49 3/50 0/50 0/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/48 0/49 1/48 1/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/48 0/49 3/48 0/48 COMBINED 0/48 0/49 4/48 1/48
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Brain:
GLIOMA 0/50 1/50 1/48 3/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 0/47 3/49
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 6/50 8/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 0/50 5/50 6/50 COMBINED 7/50 6/50 12/50 15/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Uterus/Cervix:
ADENOMA 0/50 1/50 1/47 6/48, ADENOCARCINOMA 0/50 2/50 3/47 19/48, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/47 3/48 COMBINED 0/50 4/50 5/47 27/48
|
