Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Pentaerythritol tetranitrate: Target Organs and Levels of Evidence for TR-365

Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
Pentaerythritol tetranitrate
FR: 0, 6200, 12500, MR&M: 0, 25000, 50000 PPM
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: ADENOMA 0/49 1/45 0/41; CARCINOMA 0/49 2/45 2/41
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: ADENOMA 0/36 0/37 2/35; CARCINOMA 0/36 1/37 1/35
Male Mice: No Evidence
Female Mice: No Evidence