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Target Organs and Levels of Evidence for TR-366

Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Hydroquinone 123-31-9	10/03/1988	Gavage R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP	American Biogenics Corp (Bioassay Systems)

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: Adenoma 0/55 4/55 8/55

Female Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: Leukemia 9/55 15/55 22/55

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Thyroid Gland: Follicular cell, hyperplasia Liver: Anisokaryosis; basophilic focus; syncytial alteration

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55
Non-Neoplastic Lesions	Thyroid Gland: Follicular cell, hyperplasia