Hydroquinone: Target Organs and Levels of Evidence for TR-366
Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Hydroquinone
123-31-9 | 10/03/1988 | Gavage
R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP | American Biogenics Corp (Bioassay Systems) |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
Adenoma 0/55 4/55 8/55
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
Leukemia 9/55 15/55 22/55
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Thyroid Gland: Follicular cell, hyperplasia
- Liver: Anisokaryosis; basophilic focus; syncytial alteration
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55
|
| Non-Neoplastic Lesions | - Thyroid Gland: Follicular cell, hyperplasia
|
