Hydroquinone: Target Organs and Levels of Evidence for TR-366
Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Hydroquinone 123-31-9 | 10/03/1988 | Gavage R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP | American Biogenics Corp (Bioassay Systems) |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Kidney Tubular Cell:
Adenoma 0/55 4/55 8/55
|
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Hematopoietic System:
Leukemia 9/55 15/55 22/55
|
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - Thyroid Gland: Follicular cell, hyperplasia
- Liver: Anisokaryosis; basophilic focus; syncytial alteration
|
Female Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55
|
Non-Neoplastic Lesions | - Thyroid Gland: Follicular cell, hyperplasia
|