Target Organs and Levels of Evidence for TR-366
Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Hydroquinone
123-31-9 |
10/03/1988 |
Gavage
R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP |
American Biogenics Corp (Bioassay Systems) |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: Adenoma 0/55 4/55 8/55
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Hematopoietic System: Leukemia 9/55 15/55 22/55
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Thyroid Gland: Follicular cell, hyperplasia
- Liver: Anisokaryosis; basophilic focus; syncytial alteration
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55
|
| Non-Neoplastic Lesions |
- Thyroid Gland: Follicular cell, hyperplasia
|
