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Target Organs and Levels of Evidence for TR-367

Toxicology and Carcinogenesis Studies of Phenylbutazone (CASRN 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Phenylbutazone
50-33-9		 03/13/1989 Gavage
R: 0, 50, 100, M: 0, 150, 300 MG/KG/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/49 3/50 OR CARCINOMA 0/50 1/49 0/50 COMBINED 0/50 1/49 3/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; PAPILLA, NECROSIS 1/50 10/49 24/50; COLLECTING TUBULE, MINERALIZATION 5/50 10/49 35/50
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA 0/50 0/50 2/50
May Have Been Related
  • Kidney Tubular Cell: ADENOMA (STEP SECTIONS) 0/50 3/50 1/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 1/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; PAPILLA, NECROSIS 0/50 18/50 35/50; COLLECTING TUBULE, MINERALIZATION 3/50 31/50 46/50
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50
Female Mice: No Evidence