Nalidixic acid: Target Organs and Levels of Evidence for TR-368
Toxicology and Carcinogenesis Studies of Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Nalidixic acid
389-08-2 | 03/13/1989 | Dosed-Feed
R&M: 0, 2000, 4000 PPM/50 PER GROUP | Physiological Research Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Preputial Gland:
ADENOMA 2/49 10/49 10/47, PAPILLOMA 1/49 0/49 0/47, OR CARCINOMA 0/49 10/49 12/47 COMBINED 3/49 19/49 20/47
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Clitoral Gland:
ADENOMA 4/46 10/46 11/47, PAPILLOMA 0/46 1/46 0/47, OR CARCINOMA 1/46 4/46 5/47 COMBINED 5/46 15/46 16/47
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Subcutaneous Tissue:
FIBROMA 1/50 3/50 3/50 OR FIBROSARCOMA 4/50 6/50 11/50 COMBINED 5/50 9/50 14/50
|
Female Mice: No Evidence
