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Target Organs and Levels of Evidence for TR-369

Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
alpha-Methylbenzyl alcohol
98-85-1
03/13/1989 Gavage
R&M: 0, 375, 750 MG/KG/50 PER GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, TUBULAR CELL 0/50 4/50 4/50
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: MILD NEPHROPATHY
Male Mice: No Evidence
Female Mice: No Evidence