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Target Organs and Levels of Evidence for TR-370

Toxicology and Carcinogenesis Studies of Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Benzofuran 271-89-6	03/13/1989	Gavage FR&MM: 0,60,120, MR: 0,30,60, FM: 0,120,240 MG/KG/50 PER GROUP	Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: INCREASED SEVERITY OF NEPHROPATHY

Female Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOCARCINOMA 0/50 1/50 4/50
Non-Neoplastic Lesions	KIDNEY: NEPHROPATHY 29/50 48/50 39/50 PANCREAS: METAPLASIA 0/50 1/50 11/49

Male Mice: Clear Evidence

Type

Organ/Tissue (Lesion)

Neoplastic Lesions

Liver: ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48
Forestomach: SQUAMOUS CELL PAPILLOMA 2/49 7/39 10/48 OR SQUAMOUS CELL CARCINOMA 0/49 4/39 3/48 COMBINED 2/49 11/39 13/48
Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48

Non-Neoplastic Lesions

LIVER: SYNCYTIAL ALTERATION 4/49 18/39 36/48
LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 3/49 11/39 14/48
FORESTOMACH: EPITHELIAL HYPERPLASIA 16/49 13/39 24/48

Female Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47 Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47 Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 COMBINED 2/50 9/50 5/50
Non-Neoplastic Lesions	LIVER: SYNCYTIAL ALTERATION 1/50 0/48 2/47 LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 1/50 22/48 34/47 FORESTOMACH: EPITHELIAL HYPERPLASIA 7/50 19/48 13/47