Target Organs and Levels of Evidence for TR-370
Toxicology and Carcinogenesis Studies of Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Benzofuran 271-89-6 |
03/13/1989 |
Gavage FR&MM: 0,60,120, MR: 0,30,60, FM: 0,120,240 MG/KG/50 PER GROUP |
Springborn Inst. for Bioresearch, Inc. |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOCARCINOMA 0/50 1/50 4/50
|
Non-Neoplastic Lesions |
- KIDNEY: NEPHROPATHY 29/50 48/50 39/50
- PANCREAS: METAPLASIA 0/50 1/50 11/49
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48
- Forestomach: SQUAMOUS CELL PAPILLOMA 2/49 7/39 10/48 OR SQUAMOUS CELL CARCINOMA 0/49 4/39 3/48 COMBINED 2/49 11/39 13/48
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48
|
Non-Neoplastic Lesions |
- LIVER: SYNCYTIAL ALTERATION 4/49 18/39 36/48
- LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 3/49 11/39 14/48
- FORESTOMACH: EPITHELIAL HYPERPLASIA 16/49 13/39 24/48
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47
- Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 COMBINED 2/50 9/50 5/50
|
Non-Neoplastic Lesions |
- LIVER: SYNCYTIAL ALTERATION 1/50 0/48 2/47
- LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 1/50 22/48 34/47
- FORESTOMACH: EPITHELIAL HYPERPLASIA 7/50 19/48 13/47
|