Target Organs and Levels of Evidence for TR-376
Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Allyl glycidyl ether 106-92-3 |
06/27/1989 |
Inhalation R&M: 0,5,10 PPM/50 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/44 0/46 1/43; ADENOCARCINOMA 0/44 0/46 1/43; SQUAMOUS CELL CARCINOMA 0/44 0/46 1/43
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION 9/44 27/46 18/43; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/44 19/46 35/43; RESPIRATORY EPITHELIUM, HYPERPLASIA 4/44 33/46 30/43; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 4/44 40/46 38/43; OLFACTORY EPITHELIUM, DEGENERATION 0/44 45/46 43/43
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION 5/49 7/48 11/47; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/48 31/47; RESPIRATORY EPITHELIUM, HYPERPLASIA 1/49 18/48 22/47; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 37/48 38/47; OLFACTORY EPITHELIUM, DEGENERATION 0/49 46/48 47/47
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/50 0/50 3/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION 2/50 48/50 47/50; OLFACTORY EPITHELIUM, METAPLASIA 4/50 49/50 50/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/50 25/50 40/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/50 1/50 7/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/50 4/50 8/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/50 1/50 3/50
|
Female Mice: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/49 0/49 1/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION 8/49 48/49 49/50; OLFACTORY EPITHELIUM, METAPLASIA 7/49 48/49 49/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/49 39/49 48/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/49 12/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/49 2/49 7/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/49 0/49 3/50
|