Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/12451

Target Organs and Levels of Evidence for TR-376

Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Allyl glycidyl ether
106-92-3		 06/27/1989 Inhalation
R&M: 0,5,10 PPM/50 PER GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/44 0/46 1/43; ADENOCARCINOMA 0/44 0/46 1/43; SQUAMOUS CELL CARCINOMA 0/44 0/46 1/43
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 9/44 27/46 18/43; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/44 19/46 35/43; RESPIRATORY EPITHELIUM, HYPERPLASIA 4/44 33/46 30/43; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 4/44 40/46 38/43; OLFACTORY EPITHELIUM, DEGENERATION 0/44 45/46 43/43
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 5/49 7/48 11/47; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/48 31/47; RESPIRATORY EPITHELIUM, HYPERPLASIA 1/49 18/48 22/47; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 37/48 38/47; OLFACTORY EPITHELIUM, DEGENERATION 0/49 46/48 47/47
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 3/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 2/50 48/50 47/50; OLFACTORY EPITHELIUM, METAPLASIA 4/50 49/50 50/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/50 25/50 40/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/50 1/50 7/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/50 4/50 8/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/50 1/50 3/50
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/49 0/49 1/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION 8/49 48/49 49/50; OLFACTORY EPITHELIUM, METAPLASIA 7/49 48/49 49/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/49 39/49 48/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/49 12/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/49 2/49 7/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/49 0/49 3/50