Furfural: Target Organs and Levels of Evidence for TR-382
Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Furfural
98-01-1 | 11/20/1989 | Gavage
R: 0,30,60, M: 0,50,100,175 MG/KG/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CHOLANGIOCARCINOMA 0/50 0/50 2/50
|
| Non-Neoplastic Lesions | - LIVER: BILE DUCT, DYSPLASIA AND FIBROSIS
|
Female Rats: No Evidence
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50
|
| May Have Been Related | - Kidney Tubular Cell:
ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 1/50 3/50 5/50 8/50
|
| May Have Been Related | - Forestomach:
SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50
|
