Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9122

Target Organs and Levels of Evidence for TR-382

Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Furfural
98-01-1		 11/20/1989 Gavage
R: 0,30,60, M: 0,50,100,175 MG/KG/50 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOCARCINOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • LIVER: BILE DUCT, DYSPLASIA AND FIBROSIS
Female Rats: No Evidence
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50
May Have Been Related
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 3/50 5/50 8/50
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50