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Furfural: Target Organs and Levels of Evidence for TR-382

Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
R: 0,30,60, M: 0,50,100,175 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOCARCINOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
Female Rats: No Evidence
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50
May Have Been Related
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 3/50 5/50 8/50
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50