Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9124

1-Amino-2,4-dibromoanthraquinone: Target Organs and Levels of Evidence for TR-383

Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
1-Amino-2,4-dibromoanthraquinone
81-49-2		06/21/1994Dosed-Feed
R: 0,.2,.5,1.0,2.0, M: 0,1.0,2.0 %/50 PER GROUP		T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50
  • Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50
  • Kidney Tubular Cell: ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
  • URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
  • SEMINAL VESICLE: ATROPHY
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48
  • Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49
  • Kidney Tubular Cell: ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46
Non-Neoplastic Lesions
  • LIVER: CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
  • URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA; FAT PROLIFERATION
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HEPATOCYTE HYPERTROPHY; BASOPHILIC FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE PIGMENTATION
  • FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE PIGMENTATION
  • FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION