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Target Organs and Levels of Evidence for TR-383

Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1-Amino-2,4-dibromoanthraquinone
81-49-2		 06/21/1994 Dosed-Feed
R: 0,.2,.5,1.0,2.0, M: 0,1.0,2.0 %/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50
  • Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50
  • Kidney Tubular Cell: ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
  • URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
  • SEMINAL VESICLE: ATROPHY
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48
  • Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49
  • Kidney Tubular Cell: ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46
Non-Neoplastic Lesions
  • LIVER: CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
  • URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA; FAT PROLIFERATION
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HEPATOCYTE HYPERTROPHY; BASOPHILIC FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE PIGMENTATION
  • FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
  • KIDNEY: RENAL TUBULE PIGMENTATION
  • FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION