Target Organs and Levels of Evidence for TR-383
Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1-Amino-2,4-dibromoanthraquinone 81-49-2 |
06/21/1994 |
Dosed-Feed R: 0,.2,.5,1.0,2.0, M: 0,1.0,2.0 %/50 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50
- Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50
- Kidney Tubular Cell: ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50
- Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50
|
Non-Neoplastic Lesions |
- LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
- KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
- URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA
- FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
- SEMINAL VESICLE: ATROPHY
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48
- Large Intestines: ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49
- Kidney Tubular Cell: ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48
- Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46
|
Non-Neoplastic Lesions |
- LIVER: CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
- KIDNEY: RENAL TUBULE HYPERPLASIA; RENAL TUBULE PIGMENTATION; TRANSITIONAL CELL HYPERPLASIA
- URINARY BLADDER: TRANSITIONAL CELL HYPERPLASIA; SQUAMOUS METAPLASIA; FAT PROLIFERATION
- FORESTOMACH: SQUAMOUS HYPERPLASIA; HYPERKERATOSIS; ULCER; INFLAMMATION
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HEPATOCYTE HYPERTROPHY; BASOPHILIC FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
- KIDNEY: RENAL TUBULE PIGMENTATION
- FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49
|
Non-Neoplastic Lesions |
- LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS; PIGMENTATION
- KIDNEY: RENAL TUBULE PIGMENTATION
- FORESTOMACH: HYPERPLASIA; BASAL CELL HYPERPLASIA; HYPERKERATOSIS; INFLAMMATION
|