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Target Organs and Levels of Evidence for TR-384

Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CASRN 96-18-4) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
1,2,3-Trichloropropane 96-18-4	07/09/1991	Gavage R: 0,3,10,30, M: 0,6,20,60 MG/KG	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52 Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52 Pancreas Acinar Cell: ADENOMA 5/50 21/50 36/49 29/52 Kidney Tubular Cell: ADENOMA 0/50 2/50 20/49 21/52 Preputial Gland: ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50 Zymbal Gland: CARCINOMA 0/60 0/60 0/59 3/60
May Have Been Related	Large Intestines: ADENOCARCINOMA 0/50 0/50 2/48 1/52
Non-Neoplastic Lesions	FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA PANCREAS: ACINAR HYPERPLASIA KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY PREPUTIAL GLAND:FOCAL HYPERPLASIA

Female Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52 Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52 Clitoral Gland: ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51 Mammary Gland: ADENOCARCINOMA 1/50 6/49 12/52 21/52 Zymbal Gland: CARCINOMA 0/60 1/59 0/60 4/60
May Have Been Related	Large Intestines: ADENOCARCINOMA 0/49 0/47 1/52 2/52
Non-Neoplastic Lesions	FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA PANCREAS: ACINAR HYPERPLASIA KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY CLITORAL GLAND: FOCAL HYPERPLASIA

Male Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56 Liver: ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56 Harderian Gland: ADENOMA 1/52 2/51 10/54 11/56
May Have Been Related	Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56
Non-Neoplastic Lesions	FORESTOMACH: SQUAMOUS HYPERPLASIA LIVER: EOSINOPHILIC FOCUS

Female Mice: Clear Evidence

Type

Organ/Tissue (Lesion)

Neoplastic Lesions

Oral Cavity: SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55
Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55
Liver: ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55
Harderian Gland: ADENOMA 2/50 6/50 7/51 10/55
Uterus/Cervix: ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54

Non-Neoplastic Lesions

FORESTOMACH: SQUAMOUS HYPERPLASIA
LIVER: EOSINOPHILIC FOCUS