Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9126

1,2,3-Trichloropropane: Target Organs and Levels of Evidence for TR-384

Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CASRN 96-18-4) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
1,2,3-Trichloropropane
96-18-4		07/09/1991Gavage
R: 0,3,10,30, M: 0,6,20,60 MG/KG		T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52
  • Pancreas Acinar Cell: ADENOMA 5/50 21/50 36/49 29/52
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 20/49 21/52
  • Preputial Gland: ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50
  • Zymbal Gland: CARCINOMA 0/60 0/60 0/59 3/60
May Have Been Related
  • Large Intestines: ADENOCARCINOMA 0/50 0/50 2/48 1/52
Non-Neoplastic Lesions
  • FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA
  • PANCREAS: ACINAR HYPERPLASIA
  • KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY
  • PREPUTIAL GLAND:FOCAL HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52
  • Clitoral Gland: ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51
  • Mammary Gland: ADENOCARCINOMA 1/50 6/49 12/52 21/52
  • Zymbal Gland: CARCINOMA 0/60 1/59 0/60 4/60
May Have Been Related
  • Large Intestines: ADENOCARCINOMA 0/49 0/47 1/52 2/52
Non-Neoplastic Lesions
  • FORESTOMACH: BASAL CELL AND SQUAMOUS HYPERPLASIA
  • PANCREAS: ACINAR HYPERPLASIA
  • KIDNEY: TUBULAR HYPERPLASIA; NEPHROPATHY
  • CLITORAL GLAND: FOCAL HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56
  • Liver: ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56
  • Harderian Gland: ADENOMA 1/52 2/51 10/54 11/56
May Have Been Related
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
  • LIVER: EOSINOPHILIC FOCUS
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55
  • Liver: ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55
  • Harderian Gland: ADENOMA 2/50 6/50 7/51 10/55
  • Uterus/Cervix: ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
  • LIVER: EOSINOPHILIC FOCUS