https://ntp.niehs.nih.gov/go/9128

Target Organs and Levels of Evidence for TR-385

Toxicology and Carcinogenesis Studies of Methyl Bromide (CASRN 74-83-9) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Methyl bromide
74-83-9		 11/19/1990 Inhalation
MICE ONLY:0,10,33,100 PPM		 Brookhaven National Lab (DOE)

Levels of Evidence

Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: DEGENERATIVE CHANGES IN CEREBELLUM AND CEREBRUM
  • HEART: MYOCARDIAL DEGENERATION AND CARDIOMYOPATHY
  • BONE: STERNAL DYSPLASIA
  • NOSE: OLFACTORY EPITHELIAL NECROSIS AND METAPLASIA
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: DEGENERATIVE CHANGES IN CEREBELLUM AND CEREBRUM
  • HEART: MYOCARDIAL DEGENERATION AND CARDIOMYOPATHY
  • BONE: STERNAL DYSPLASIA
  • NOSE: OLFACTORY EPITHELIAL NECROSIS AND METAPLASIA
 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Methyl bromide
74-83-9		   Inhalation
R: 0,30,120, M: 0,10,120 PPM/10 PER GROUP		 Brookhaven National Lab (DOE)

Levels of Evidence: None