Tetranitromethane: Target Organs and Levels of Evidence for TR-386
Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Tetranitromethane
509-14-8 | 11/20/1989 | Inhalation
R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP | Midwest Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50
|
| Non-Neoplastic Lesions | - NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA, SQUAMOUS METAPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50
|
| Non-Neoplastic Lesions | - NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50
|
| Non-Neoplastic Lesions | - NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50
|
| Non-Neoplastic Lesions | - NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
