Target Organs and Levels of Evidence for TR-386
Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetranitromethane
509-14-8 |
11/20/1989 |
Inhalation
R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP |
Midwest Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50
|
| Non-Neoplastic Lesions |
- NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA, SQUAMOUS METAPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50
|
| Non-Neoplastic Lesions |
- NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50
|
| Non-Neoplastic Lesions |
- NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50
|
| Non-Neoplastic Lesions |
- NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
|
