Target Organs and Levels of Evidence for TR-388
Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Ethylene thiourea (ETU)
96-45-7 |
04/25/1990 |
Dosed-Feed
R: 0,25,83,250, M: 0,100,333,1000 PPM/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50
- Liver: ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50
- Pituitary Gland: ADENOMA 0/44 0/42 8/41
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
- LIVER: CYTOMEGALY
- PITUITARY GLAND: FOCAL HYPERPLASIA
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50
- Liver: ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50
- Pituitary Gland: ADENOMA 10/47 19/49 26/49; CARCINOMA 1/47 0/49 0/49
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
- LIVER: CYTOMEGALY
- PITUITARY GLAND: FOCAL HYPERPLASIA
|
