Tris(2-Chloroethyl) Phosphate: Target Organs and Levels of Evidence for TR-391
Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
tris(2-Chloroethyl) phosphate
115-96-8 | 04/25/1990 | Gavage
R: 0,44,88; M: 0,175,350 MG/KG/60 PER GROUP | BioReliance, Inc |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 1/50 5/50 24/50
|
| May Have Been Related | - Thyroid Gland Follicular Cell:
ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50
- Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50
|
| Non-Neoplastic Lesions | |
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 2/50 5/50
|
| May Have Been Related | - Thyroid Gland Follicular Cell:
ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50
- Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50
|
| Non-Neoplastic Lesions | - KIDNEY: HYPERPLASIA
- BRAIN: GLIOSIS; HEMORRHAGE; PIGMENTATION; MINERALIZATION
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 1/50 1/50 3/50
|
| Non-Neoplastic Lesions | |
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Harderian Gland:
ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50
|
| Non-Neoplastic Lesions | |
