Target Organs and Levels of Evidence for TR-394
Toxicology and Carcinogenesis Studies of Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Acetaminophen (4-hydroxyacetanilide) 103-90-2 |
11/19/1990 |
Dosed-Feed R&M:0,.06,.3,.6%/60 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA
- PARATHYROID GLAND: HYPERPLASIA
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 9/50 17/50 15/50 24/50
|
Non-Neoplastic Lesions |
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|