Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Probenecid: Target Organs and Levels of Evidence for TR-395

Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
R&M:0,100,400 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 24/50 23/50 5/50
Male Mice: No Evidence
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/48 2/49 14/49, CARCINOMA 2/48 2/49 3/49, COMBINED 5/48 3/49 16/49