Target Organs and Levels of Evidence for TR-398
Toxicology and Carcinogenesis Studies of Polybrominated Biphenyls (Firemaster FF-1") (CASRN 67774-32-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Polybrominated biphenyl mixture (Firemaster FF-1)
67774-32-7 |
06/23/1992 |
Dosed-Feed
R & M: 0, 1, 3, 10, AND 30 PPM/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 1/50 10/49 38/50 OR CARCINOMA 0/50 2/49 19/50 COMBINED 1/50 12/49 41/50
|
| Non-Neoplastic Lesions |
- LIVER: HYPERTROPHY; EOSINOPHILIC FOCUS; CYTOPLASMIC VACUOLIZATION; OVAL CELL HYPERPLASIA
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 0/50 10/50 38/50 OR CARCINOMA 0/50 2/50 4/50 COMBINED 0/50 12/50 39/50
|
| Non-Neoplastic Lesions |
- LIVER: HYPERTROPHY; EOSINOPHILIC FOCUS; CYTOPLASMIC VACUOLIZATION; OVAL CELL HYPERPLASIA
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 9/50 48/49 42/50; CARCINOMA 8/50 30/49 36/50
|
| Non-Neoplastic Lesions |
- LIVER: CYTOMEGALY; FATTY CHANGE; BILE DUCT HYPERPLASIA
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 4/50 39/50 46/48; CARCINOMA 1/50 22/50 35/48
|
| Non-Neoplastic Lesions |
- LIVER: CYTOMEGALY; FATTY CHANGE
|
