https://ntp.niehs.nih.gov/go/10969

Target Organs and Levels of Evidence for TR-399

Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Titanocene dichloride
1271-19-8		 11/19/1990 Gavage
RATS ONLY:0,25,50 MG/KG/80 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/60 4/60 1/60; BENIGN BASOSQUAMOUS TUMOR 0/60 0/60 1/60; SQUAMOUS CELL CARCINOMA 0/60 1/60 0/60
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION
  • FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS
  • LIVER: GRANULOMATOUS INFLAMMATION
  • VARIOUS ORGANS: PIGMENTATION
  • LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION
  • NASAL CAVITY: ACUTE INFLAMMATION
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/60 1/60 2/60
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION
  • FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS
  • LIVER: GRANULOMATOUS INFLAMMATION
  • VARIOUS ORGANS: PIGMENTATION
  • LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION
  • NASAL CAVITY: ACUTE INFLAMMATION