Target Organs and Levels of Evidence for TR-399
Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Titanocene dichloride
1271-19-8 |
11/19/1990 |
Gavage
RATS ONLY:0,25,50 MG/KG/80 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/60 4/60 1/60; BENIGN BASOSQUAMOUS TUMOR 0/60 0/60 1/60; SQUAMOUS CELL CARCINOMA 0/60 1/60 0/60
|
| Non-Neoplastic Lesions |
- GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION
- FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS
- LIVER: GRANULOMATOUS INFLAMMATION
- VARIOUS ORGANS: PIGMENTATION
- LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION
- NASAL CAVITY: ACUTE INFLAMMATION
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/60 1/60 2/60
|
| Non-Neoplastic Lesions |
- GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION
- FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS
- LIVER: GRANULOMATOUS INFLAMMATION
- VARIOUS ORGANS: PIGMENTATION
- LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION
- NASAL CAVITY: ACUTE INFLAMMATION
|
