Target Organs and Levels of Evidence for TR-400
Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2,3-Dibromo-1-propanol 96-13-9 |
06/23/1992 |
Topical Application R: 0,188,375, M: 0,88,177 MG/KG/50 PER GROUP |
Papanicolaou Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/50 48/50 48/50
- Mesothelium (Abdominal Cavity/Tunica Vaginalis): 0/50 1/50 4/50
- Vascular System (Spleen): HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50
- Skin: SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50
- Esophagus: SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50
- Intestines: ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50
- Liver: NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50
- Kidney Tubular Cell: ADENOMA 0/50 0/50 4/50
- Zymbal Gland: ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50
|
Non-Neoplastic Lesions |
- SKIN: HYPERKERATOSIS
- NASAL CAVITY: EPITHELIAL DYSPLASIA
- ESOPHAGUS: HYPERKERATOSIS
- FORESTOMACH: HYPERKERATOSIS; ULCER; ACANTHOSIS
- LIVER: PLEOMORPHISM; BASOPHILIC CHANGE; CLEAR CELL CHANGE; ANGIECTASIS
- KIDNEY: NUCLEAR ENLARGEMENT; HYPERPLASIA
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Skin: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50
- Zymbal Gland: ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50
- Clitoral Gland: ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50
- Mammary Gland: ADENOCARCINOMA 0/50 0/50 5/50
- Nasal Cavity: ADENOMA 0/50 44/50 49/50
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50
- Esophagus: SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50
- Intestines: ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50
- Liver: NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50
- Kidney Tubular Cell: ADENOMA 0/50 1/50 4/50
|
Non-Neoplastic Lesions |
- SKIN: HYPERKERATOSIS
- NASAL CAVITY: EPITHELIAL DYSPLASIA
- ESOPHAGUS: HYPERKERATOSIS
- FORESTOMACH: HYPERKERATOSIS; EPITHELIAL DYSPLASIA
- LIVER: PLEOMORPHISM; BASOPHILIC CHANGE; CLEAR CELL CHANGE; BILE DUCT HYPERPLASIA
- KIDNEY: NUCLEAR ENLARGEMENT
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Skin: SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49
- Liver: ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50
|
Non-Neoplastic Lesions |
- SKIN: HYPERPLASIA
- FORESTOMACH: EPITHELIAL DYSPLASIA
- LUNG: BRONCHIAL EPITHELIAL PLEOMORPHISM; FOCAL HYPERPLASIA
- LIVER: EOSINOPHILIC CYTOPLASMIC CHANGE
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Skin: SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50
|
May Have Been Related |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50
|
Non-Neoplastic Lesions |
- SKIN: HYPERPLASIA
- FORESTOMACH: EPITHELIAL DYSPLASIA
- LUNG: BRONCHIAL PLEOMORPHISM; FOCAL HYPERPLASIA
|