https://ntp.niehs.nih.gov/go/10973

Target Organs and Levels of Evidence for TR-401

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
2,4-Diaminophenol dihydrochloride
137-09-7		 03/11/1991 Gavage
R: 0,12.5,25, M: 0,19,38 MG/KG/60 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE, HYPERPLASIA, FOCAL; INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE, HYPERPLASIA, FOCAL; NEPHROPATHY
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/48 3/50
Non-Neoplastic Lesions
  • KIDNEY: NECROSIS; RENAL TUBULE, REGENERATION; RENAL TUBULE, HYPERPLASIA; RENAL TUBULE, DILATATION
  • FORESTOMACH: ACANTHOSIS
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NECROSIS; RENAL TUBULE, REGENERATION