Target Organs and Levels of Evidence for TR-401
NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2,4-Diaminophenol dihydrochloride
137-09-7 |
03/11/1991 |
Gavage
R: 0,12.5,25, M: 0,19,38 MG/KG/60 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: RENAL TUBULE, HYPERPLASIA, FOCAL; INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: RENAL TUBULE, HYPERPLASIA, FOCAL; NEPHROPATHY
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 0/48 3/50
|
| Non-Neoplastic Lesions |
- KIDNEY: NECROSIS; RENAL TUBULE, REGENERATION; RENAL TUBULE, HYPERPLASIA; RENAL TUBULE, DILATATION
- FORESTOMACH: ACANTHOSIS
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: NECROSIS; RENAL TUBULE, REGENERATION
|
