Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13762

Furan: Target Organs and Levels of Evidence for TR-402

Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Furan
110-00-9		03/11/1991Gavage
R: 0,2,4,8, M: 0,8,15 MG/KG/50 PER GROUP		Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • LIVER: (BILIARY TRACT) DILATATION, FIBROSIS, HYPERPLASIA, AND INFLAMMATION, CHRONIC; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS
  • PARATHYROID GLAND: HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS
  • PARATHYROID GLAND: HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/49 6/50 10/50
Non-Neoplastic Lesions
  • LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 1/50 6/50
Non-Neoplastic Lesions
  • LIVER: (BILIARY TRACT) DILATATION, CHRONIC INFLAMMATION, FIBROSIS, HYPERPLASIA; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS