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Target Organs and Levels of Evidence for TR-402

Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Furan
110-00-9		 03/11/1991 Gavage
R: 0,2,4,8, M: 0,8,15 MG/KG/50 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • LIVER: (BILIARY TRACT) DILATATION, FIBROSIS, HYPERPLASIA, AND INFLAMMATION, CHRONIC; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS
  • PARATHYROID GLAND: HYPERPLASIA
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
  • LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS
  • PARATHYROID GLAND: HYPERPLASIA
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/49 6/50 10/50
Non-Neoplastic Lesions
  • LIVER: (BILIARY TRACT) CHRONIC FOCAL INFLAMMATION, CYST, FOCAL FIBROSIS, FOCAL HYPERPLASIA, METAPLASIA; (HEPATOCYTE) CYTOMEGALY, CYTOPLASMIC VACUOLIZATION, FOCAL DEGENERATION, FOCAL HYPERPLASIA, FOCAL NECROSIS
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 1/50 6/50
Non-Neoplastic Lesions
  • LIVER: (BILIARY TRACT) DILATATION, CHRONIC INFLAMMATION, FIBROSIS, HYPERPLASIA; (HEPATOCYTE) CYTOMEGALY, DEGENERATION, NECROSIS