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Target Organs and Levels of Evidence for TR-406

Toxicology and Carcinogenesis Studies of g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
gamma-Butyrolactone
96-48-0
07/09/1991 Gavage
MR: 0, 112, OR 225 MG/KG FR: 0, 225, OR 450 MG/KG M: 0, 262, OR 525 MG/KG; 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Other Considerations
  • MAMMARY GLAND: CYST 42/50 35/50 23/50; FIBROADENOMA 22/50 14/50 6/50
  • PITUITARY GLAND: CYST 25/49 13/37 11/48
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/48 5/50 1/50 OR MALIGNANT PHEOCHROMOCYTOMA 1/48 1/50 0/50 COMBINED 2/48 6/50 1/50
Non-Neoplastic Lesions
  • ADRENAL GLAND: HYPERPLASIA
Other Considerations
  • LIVER: ADENOMA 8/50 6/50 1/50 OR CARCINOMA 16/50 2/50 8/50 COMBINED 24/50 8/50 9/50
Female Mice: No Evidence