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Target Organs and Levels of Evidence for TR-408

Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Mercuric chloride 7487-94-7	07/10/1991	Gavage R: 0,2.5,5, M: 0,5,10 MG/KG/60 PER GROUP	International Research & Development Corp.

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50
May Have Been Related	Thyroid Gland Follicular Cell: ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50
Non-Neoplastic Lesions	KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA FORESTOMACH: PAPILLARY HYPERPLASIA NASAL CAVITY: INFLAMMATION

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/49 2/50
Non-Neoplastic Lesions	FORESTOMACH: PAPILLARY HYPERPLASIA NASAL CAVITY: INFLAMMATION

Male Mice: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA 0/50 0/50 2/49 OR ADENOCARCINOMA 0/50 0/50 1/49
Non-Neoplastic Lesions	KIDNEY: NEPHROPATHY NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: NEPHROPATHY NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA